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Updated: Jul 16, 2025

Spatial and Temporal Analysis of Active ERK in the C. elegans Germline
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Spatial and Temporal Analysis of Active ERK in the C. elegans Germline

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DMRT1调节了人类生殖系的承诺

Naoko Irie1,2, Sun-Min Lee3,4, Valentina Lorenzi5,6

  • 1Wellcome Trust/Cancer Research UK Gurdon Institute, Henry Wellcome Building of Cancer and Developmental Biology, Cambridge, UK. irienaoko@ciea.or.jp.

Nature cell biology
|September 14, 2023
PubMed
概括

研究人员追踪了人类胚胎干细胞衍生细胞,发现特定的信号分子促进了原始生殖细胞类细胞的发展. 这一过程涉及表观遗传的重置,对生殖线的承诺和潜在的体外生殖细胞产生至关重要.

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Inducible and Reversible Dominant-negative DN Protein Inhibition

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相关概念视频

Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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