与虫类基因型的共同感染推动了不同的感染动态,反映了区域分布模式
Tamilie Carvalho1,2, Daniel Medina3,4,5, Luisa P Ribeiro3
1Laboratório de História Natural de Anfíbios Brasileiros (LaHNAB), Departamento de Biologia Animal, Instituto de Biologia, Unicamp, Campinas, São Paulo, Brazil. tamilie@umich.edu.
Communications biology
|September 14, 2023
概括
全球化可能会增加病原体的毒性. 在巴西,两动物贸易导致了新的Batrachochytrium dendrobatidis (Bd) 基因型,同时感染导致严重下降. 共感染动态揭示了全球化如何促进高病毒性病原体的出现.
科学领域:
- 生态生态学 生态生态学
- 病原体的进化 病原体的进化
- 保护生物学 保护生物学
背景情况:
- 全球化和贸易可以改变病原体的动态和毒性.
- 两动物贸易在巴西的大西洋森林中引入了致病性菌菌的新型病毒性基因型,Batrachochytrium dendrobatidis (Bd).
- 与不同Bd基因型的同时感染与两动物严重的减少有关.
研究的目的:
- 研究涉及不同Batrachochytrium dendrobatidis (Bd) 基因型的共感染如何影响病原体的毒性和传播.
- 了解全球化可能为高病毒性病原体血统选择的机制.
主要方法:
- 对共感染动态的实验研究.
- 流行病学数据与实验结果的整合.
- 对基因型竞争,毒性和共感染下传播的分析.
主要成果:
- 同感染有利于更具毒性的泛动物性Bd基因型,减少了其传播和整体毒性.
- 同感染增加了最不具毒性,最不具竞争力的Bd基因型的毒性和传播.
- 与共感染的混合区显示了两动物最严重的下降.
结论:
- 同感染动态在塑造病原体的毒性和传播方面发挥着至关重要的作用.
- 全球化可能无意中选择并促进过度病毒性病原体血统的出现.
- 了解这些机制对于两动物的保护和管理新出现的传染病至关重要.
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