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Updated: Jul 16, 2025

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
11:06

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells

Published on: February 24, 2014

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截断Ppm1d突变促进了基因毒性压力诱导的AML的发展

Monika Burocziova1,2, Petr Danek2, Anna Oravetzova1

  • 1Department Cancer Cell Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Prague, Czech Republic.

Leukemia
|September 14, 2023
PubMed
概括

蛋白质酸酶依赖1三角体 (PPM1D) 的切断突变破坏了造血干细胞 (HSC) 功能,在辐射后促进了侵袭性白血病. 抑制PPM1D可能为治疗诱导的AML提供治疗策略.

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