母亲周周孕期叶酸补充剂和胎儿先天性尿生系统缺陷的风险
Zixi Pang1,2, Lei Jin3, Jie Zhang1,2
1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China.
Pediatric research
|September 14, 2023
概括
孕妇在怀孕早期服用叶酸 (FA) 或多重微量营养素 (MMFA) 补充剂可能会降低婴儿发生生殖尿路先天缺陷的风险. 这包括降低患下症的风险,这是一个常见的男性出生缺陷.
科学领域:
- 产科和妇科 产科和妇科
- 儿科手术 儿科手术
- 公共卫生 公共卫生
背景情况:
- 已知叶酸 (FA) 补充剂可以减少神经管缺陷.
- 对于FA对其他先天性异常,如生殖尿道 (GU) 缺陷的影响,人们对其理解程度仍然较低.
- 调查FA在预防GU缺陷中的作用对于全面的产前护理至关重要.
研究的目的:
- 检查受孕期间服用叶酸或多种微量营养素补充剂与生殖尿路先天缺陷风险之间的关联.
- 为了具体评估对低度的影响,一个常见的GU异常.
主要方法:
- 利用了来自北京产前保健和出生缺陷监测系统的2013-2018年的数据.
- 员工倾向得分对共变量调整的反向概率加权.
- 应用Poisson回归建模来评估风险关联.
主要成果:
- 包括65,418个出生;发现了194例先天性GU缺陷的病例.
- 与非使用者 (34.9/10,000) 相比,FA/MMFA使用者的GU缺陷患病率降低 (29.2/10,000).
- 使用FA/MMFA与较低的GU缺陷风险 (aRR0.81) 和hypospadias (aRR0.55) 相关.
结论:
- 孕期叶酸或MMFA补充剂可以保护后代免受生殖泌尿系统的先天缺陷.
- 母亲FA/MMFA补充剂似乎可以降低低血压的风险.
- 需要进一步的研究来阐明这种保护作用背后的机制.
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