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Updated: Jul 16, 2025

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
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Published on: July 27, 2021

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全基因组关联元分析确定了与非酒精性脂肪肝疾病相关的17个位点

Yanhua Chen1, Xiaomeng Du1, Annapurna Kuppa1

  • 1Department of Internal Medicine, Division of Gastroenterology and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.

Nature genetics
|September 14, 2023
PubMed
概括

这项研究确定了与非酒精性脂肪性肝病 (NAFLD) 相关的遗传变异,突出了其遗传性和潜在的亚型. 这些发现改善了NAFLD风险评估,并可能指导新的治疗开发.

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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