在2022年之前,在人类中共循环的明显的水病毒系
Nnaemeka Ndodo1, Jonathan Ashcroft2, Kuiama Lewandowski3
1Nigeria Centre for Disease Control, Abuja, Nigeria.
Nature medicine
|September 14, 2023
概括
在2022年之前的几年里,尼日利亚流传了多种麻疹病毒 (MPXV) 血统,显示出适应潜力. 基因组数据显示了突变,包括A.2血统,突出显示了持续的人与人之间的传播和病毒进化.
科学领域:
- 病毒学 病毒学
- 基因组学就是基因组学.
- 流行病学 流行病学
背景情况:
- 2022年全球mopox疫情突出了了解麻疹病毒 (MPXV) 人类传播和适应方面的差距.
- 由于基因组数据有限,2017年尼日利亚疫情和2022年全球mopox爆发之间的进化联系尚不清楚.
研究的目的:
- 调查2018年至2022年间尼日利亚MPXV的基因组多样性和进化史.
- 为了确定出口的MPXV系的起源,包括A.2系.
主要方法:
- 来自尼日利亚南部的18个MPXV分离物的全基因组测序 (2019-2020年).
- 遗传学分析以确定血统关系和进化途径.
- 特定突变的识别,包括与APOBEC3活动相关的突变.
主要成果:
- 在2022年之前的几年里,多个MPXV血统在尼日利亚人类中共同循环.
- 以前独立出口的A.2血统起源于尼日利亚,并通过人与人之间的传播持续了两年多.
- 在A.2分离物的A46R基因中发现了一种定义血统的APOBEC3相关突变,可能会影响病毒免疫调节.
结论:
- MPXV表明了人类群体内持续多样化和适应的能力.
- 在流行地区了解疫情爆发前的病毒演变对于预测和控制未来的mopox流行病至关重要.
- 在人类溢出事件期间,APOBEC3介导的突变可能在MPXV的适应和进化中发挥作用.
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