在患有阻塞性睡眠呼吸暂停的患者中,小脑体积和内在小脑网络
Jinseung Kim1, Ho-Joon Lee2, Dong Ah Lee3
1Department of Family Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Sleep & breathing = Schlaf & Atmung
|September 14, 2023
概括
阻塞性睡眠呼吸暂停 (OSA) 患者的总大脑体积减少,特别是在特定区域,如左叶 VIIB. 这表明小脑可能在OSA的机制中发挥作用.
科学领域:
- 神经成像是一种神经成像.
- 睡眠医学 睡眠医学
- 小脑神经科学是神经科学.
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种常见的疾病,已知具有系统性影响.
- 小脑在OSA病理生理学中的作用仍未得到充分研究.
- 了解OSA中的结构性大脑变化对于全面管理至关重要.
研究的目的:
- 调查OSA患者小脑体积的变化.
- 在OSA中检查内在小脑网络的功能连接.
- 为了将小脑变化与OSA严重程度相关联.
主要方法:
- 招募新诊断的OSA患者和健康对照组.
- 在3T扫描仪上获得的3D T1加权MRI扫描.
- 使用图形理论进行大脑小脑体积量化 (ACAPULCO) 和内在网络分析 (BRAPH).
主要成果:
- 在OSA患者 (8.330%) 与对照组 (9.068%) 的总小脑体积显著下降.
- 在OSA患者的左叶片VIIB体积减少.
- 在OSA患者中,左叶X体积和非REM呼吸暂停-呼吸暂停指数之间的负相关性.
- 群体之间本质小脑网络没有显著差异.
结论:
- OSA与小脑总体体积的减少和特定叶片的减少有关.
- 这些小脑结构变化可能会导致OSA.
- 需要进一步的研究来阐明小脑在OSA中的确切作用.
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