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Updated: Jul 16, 2025

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BAP1突变抑制NF-κB信号通路,以诱导皮膜黑色素瘤中的免疫抑制微环境

Chao Zhang1, Shuai Wu2

  • 1Department of Strabismus and Pediatric Ophthalmology, the Second Hospital of Jilin University, Changchun, 130041, P. R. China.

Molecular medicine (Cambridge, Mass.)
|September 14, 2023
PubMed
概括

在乳膜黑色素瘤 (UM) 中的BRCA1相关蛋白1 (BAP1) 突变抑制了核因子-κB (NF-κB) 途径. 这创造了一个免疫抑制的瘤微环境,促进UM生长和转移.

关键词:
在 BAP1 中, BAP1 是 BAP1 的前身.基因突变是一种基因突变.通过NF-κB信号通路传递信号.瘤的免疫微环境在Uveal黑色素瘤.

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