肯尼亚重症监护室的多药耐药格拉姆阴性细菌感染和相关因素:一个横截面研究
Jane Wairimu Maina1,2, Frank Gekara Onyambu3, Peter Shikuku Kibet4
1Department of Medical Laboratory Science, The Nairobi West Hospital, Nairobi, Kenya. wairimuj100@gmail.com.
Annals of clinical microbiology and antimicrobials
|September 14, 2023
概括
重症监护病房的患者面临着高风险的格拉姆阴性细菌感染,特别是多药耐药菌株. 抗生素使用史,鼻胃管使用,呼吸道或心血管疾病增加了这种风险.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 公共卫生监督 公共卫生监督
背景情况:
- 重症监护室 (ICU) 的患者容易感染格拉姆阴性细菌 (GNB),包括多药耐药 (MDR) 菌株,导致发病率和死亡率增加.
- 在许多情况下,对MDR细菌的流行病学数据有限,阻碍了有效的感染预防和控制 (IPC) 策略.
研究的目的:
- 为了确定在ICU患者中GNB感染的流行率.
- 在这个患者群体中确定与GNB感染相关的因素.
主要方法:
- 一项基于医院的横截面研究于2022年1月至10月在肯尼亚内罗毕西医院进行.
- 招募了162名ICU患者,并采集了各种临床样本,用于使用BD Phoenix系统进行细菌培养和抗菌素敏感性测试.
主要成果:
- GNB感染的患病率为55.6%,其中尿路感染 (UTI) 主要.
- 大肠杆菌和肺炎Klebsiella是最常见的GNB分离物. 92%的分离物是MDR的.
- 与GNB感染相关的因素包括先前使用抗生素,鼻胃管 (NGT) 使用,呼吸道 (RT) 或心血管 (CV) 疾病.
结论:
- 在ICU中观察到MDR-GNB感染的高患病率,主要是尿道感染.
- 患有抗生素使用史,NGT使用或RT / CV疾病的患者有更高的风险.
- 持续教育和强有力的IPC措施对于管理ICU入院患者至关重要.
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