在美国成年人中,生命必需8和生物衰老之间的关联
Ronghuai Zhang1, Min Wu2, Wei Zhang1
1Department of Cardiology, Shaanxi Provincial People's Hospital, No. 256, Youyixi Road, Xi'an, 710068, Shaanxi, China.
Journal of translational medicine
|September 14, 2023
概括
通过生命必需8 (LE8) 测量较高的心血管健康得分与缓慢的生物衰老有关. 优化心血管健康可能有助于预防和减缓衰老过程.
科学领域:
- 心脏病学 心脏病学
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 生物衰老与心血管疾病 (CVD) 密切相关.
- 心血管健康 (CVH) 是衰老的一个关键因素.
- 了解CVH和生物衰老之间的相互作用对于健康跨度研究至关重要.
研究的目的:
- 为了研究生命的基本8 (LE8) 和生物衰老之间的关系.
- 为了确定心血管健康指标的改善是否与生物年龄的减少有关.
- 探索LE8组件与衰老标志物之间的关联.
主要方法:
- 采用国家健康和营养检查调查 (2005-2010) 的数据进行的横截面研究.
- 根据美国心脏协会的定义计算LE8分数,包括健康行为和因素.
- 使用表型年龄,表型年龄加速 (PhenoAgeAccel),生物年龄和生物年龄加速 (BioAgeAccel) 来评估生物衰老.
- 权重线性回归和受限立方线模型被用于相关性分析.
主要成果:
- 较高的LE8分数表明与表型年龄,生物年龄,PhenoAgeAccel和BioAgeAccel有显著的反向关联.
- 观察到非线性剂量反应关系,表明LE8得分的更大改善与较低的生物衰老标志物相对应.
- 无论是健康行为还是健康因素得分,都显示出与生物衰老的负相关性,健康因素表现出更强烈的关联,特别是血糖和血压.
结论:
- 生活必需品8 (LE8) 评分与生物衰老有着强烈的负相关.
- 通过LE8指标促进最佳心血管健康可能是预防和减缓衰老过程的关键策略.
- 旨在改善心血管健康行为和因素的干预措施可能会对健康产生重大影响,并减少与年龄相关的疾病负担.
相关概念视频
01:26Aging
86
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
86
01:19The Effect of Aging on Tissues
2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
01:37Mitochondria
13.7K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
13.7K
01:29Bone Disorders
3.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.6K
02:20Longitudinal Research
12.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.0K
01:22Life Tables
127
A life table is a statistical tool that summarizes the mortality and survival patterns of a population, providing detailed insights into the likelihood of survival or death across different age intervals within a cohort. By organizing data on survival probabilities and mortality rates, life tables offer a clear snapshot of population dynamics over time. They are extensively used in demography, public health, actuarial science, and ecology to analyze life expectancy, design health interventions,...
127