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用热加速剂进行微波除的计算建模
Jan Sebek1, William K C Park2, Shireen Geimer3,4
1Department of Electrical and Computer Engineering, Kansas State University, Manhattan, Kansas, USA.
概括
使用HeatSYNC凝进行微波切除 (MWA) 的计算模型准确预测了肝脏组织中的热概况和切除区域. 该模型有助于解释实验结果,并了解热加速剂如何影响MWA程序.
科学领域:
- 生物医学工程 生物医学工程
- 计算机建模 计算建模
- 热废弃技术的热废弃技术
背景情况:
- 微波除 (MWA) 是用于瘤治疗的微创手术.
- 热加速度凝可以提高MWA的有效性,但需要精确的建模以实现最佳应用.
- 了解MWA和加速剂凝之间的相互作用对于改善治疗结果至关重要.
研究的目的:
- 开发和验证一个模拟MWA的3D计算模型,用热加速凝 (HeatSYNC) 来模拟MWA.
- 应用该模型来解释来自ex vivo牛肝和in vivo猪肝MWA的实验数据.
- 分析HeatSYNC凝对热形状和剥离区域尺寸的影响.
主要方法:
- 实现了3D合电磁传热模型,其中包含了HeatSYNC凝的温度依赖性质.
- 通过将模拟的剥离区域范围和温度配置文件与牛肝体外活体实验测量进行比较来验证模型.
- 利用经过验证的模型预测体内猪肝的热概况,并分析观察到的剥离模式.
主要成果:
- 热SYNC凝的电导率明显高于肝脏组织,导致微波吸收增加.
- 在ex vivo牛肝中,模型对除区域尺寸的预测与实验发现非常相匹配.
- 计算分析表明,在MWA期间HeatSYNC凝在肝脏组织中扩散可以解释体内观察到的较大的切除区域.
结论:
- 集成热加速度剂的计算模型为MWA机制提供了宝贵的见解.
- 开发的模型准确地预测了使用HeatSYNC凝的MWA结果.
- 进一步细化模型可以使各种凝注射策略的MWA结果可以预测.
相关概念视频
01:20Mechanisms of Heat Transfer II
In convection, thermal energy is carried by the large-scale flow of matter. Ocean currents and large-scale atmospheric circulation, which result from the buoyancy of warm air and water, transfer hot air from the tropics toward the poles and cold air from the poles toward the tropics. The Earth’s rotation interacts with those flows, causing the observed eastward flow of air in the temperate zones. Convection dominates heat transfer by air, and the amount of available space for the airflow...
01:14Mechanisms of Heat Transfer
Heat transfer between the human body and its environment occurs through four main mechanisms: conduction, convection, radiation, and evaporation.
Conduction, accounting for approximately 3% of body heat loss at rest, is the process of exchanging heat between molecules of two materials in direct contact. This can result in both heat loss and gain. For instance, when the body is submerged in water, which conducts heat 20 times more effectively than air, it can either lose or gain significant heat.
Conduction, accounting for approximately 3% of body heat loss at rest, is the process of exchanging heat between molecules of two materials in direct contact. This can result in both heat loss and gain. For instance, when the body is submerged in water, which conducts heat 20 times more effectively than air, it can either lose or gain significant heat.