根据Bhattacharya的分析,尿液中脱甲烯的参考间隔
Bobby Li1, Richard King1, Christiaan Sies1
1Specialist Biochemistry, Canterbury Health Laboratories, Te Whatu Ora - Health New Zealand Waitaha Canterbury, Christchurch, New Zealand.
Annals of clinical biochemistry
|September 15, 2023
概括
确定了尿液中甲基内弗林的新年龄和性别分层参考间隔 (RI). 这将通过减少错误阳性结果来提高查叶染色细胞瘤或偏角细胞瘤 (PPGL) 的准确性.
科学领域:
- 内分泌学 在内分泌学.
- 临床化学 临床化学
- 诊断医学 诊断医学 诊断医学
背景情况:
- 尿液中甲基尼对于查发红细胞瘤或偏角质瘤 (PPGL) 是至关重要的.
- 现有的参考间隔 (RI) 缺乏年龄和性别分层,导致高假阳性率,特别是在高血压患者中.
- 这项研究解决了在查人群中需要精制RI的需求.
研究的目的:
- 为了确定尿液中甲基和诺米甲基分泌的年龄和性别分层参考间隔 (RI).
- 为了建立甲氨酸/肌氨酸和甲氨酸/肌氨酸比率的分层RI.
- 为了提高PPGL查的诊断准确度.
主要方法:
- 2010年至2022年间,从8221名患者 (2936名男性,5285名女性) 的24小时脱尿中甲基氨酸的分析.
- 使用液体色谱与电化学检测 (LC-ECD) 和双重质谱 (LC-MS/MS).
- 应用Bhattacharya分析对日志转换的数据来导出年龄和性别分层的RI.
主要成果:
- 诺美坦林的分泌量随着年龄的增长而增加,在不同年龄组 (18-30,30-40,40岁以上) 的男性和女性中具有明显的RI.
- 甲氨酸分泌在整个成年期保持一致,男性和女性 (18岁以上) 具有特定的RI.
- 诺尔梅他内/肌胺和甲内/肌胺的比率随着年龄的增长而增加,特别是在成年早期之后,在女性中观察到更高的比率.
结论:
- 已确定的年龄和性别分层的RI用于尿液中甲基氨酸和甲基氨酸,以及它们的肌素比率.
- 这些新的RI预计将在PPGL查中显著减少假阳性结果.
- 这些发现将有助于更准确地识别患有PPGL的患者.
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