鉴定与cuproptosis相关的基因,以预测前列腺癌的发展
Xin'an Wang1, Xi Chen1, Chengdang Xu1
1Department of Urology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
Open medicine (Warsaw, Poland)
|September 15, 2023
概括
这项研究确定了影响前列腺癌 (PCa) 进展和患者存活率的关键cuproptosis相关基因. 这些基因为预测PCa发育和预后提供了潜在的生物标志物.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 铜在癌症中的双重作用:在高度下有毒,但有可能抑制前列腺癌 (PCa) 的进展.
- 最近发现了cuproptosis机制和相关基因,其在PCa中的特定功能尚不清楚.
研究的目的:
- 研究前列腺癌 (PCa) 中与cuproptosis相关的基因的临床意义和预后价值.
- 识别潜在的基因特征,以预测PCa发育和患者的结果.
主要方法:
- 来自公共数据库的RNA测序和临床数据的分析.
- 不同基因表达分析,生存分析 (无疾病生存率) 和风险因素建模 (回归和拉索).
- 调查与cuproptosis相关的基因与免疫细胞透之间的关联;在临床样本中进行验证.
主要成果:
- 在PCa组织中确定了DLD,DLAT,PDHA1和CDKN2A的差异表达.
- FDX1,LIAS,DLAT,GLS和CDKN2A与PCa进展有关;PDHA1和CDKN2A影响了无病生存率 (DFS).
- 在西方和中国人群中,FDX1,PDHA1,MTF1和CDKN2A被确定为PCa的危险因素;这些基因也与DFS和免疫细胞透相关.
结论:
- 一种包含与cuproptosis相关的基因 (FDX1,PDHA1,MTF1,CDKN2A) 的新型基因签名可以预测PCa的发展.
- 这些基因有可能成为PCa的预后生物标志物,影响患者的结果和无病生存.
- 与cuproptosis相关的基因与免疫细胞透有关,这表明它在瘤微环境中的作用.
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