值基尼变量重要性与单训练随机森林:一个经验的贝叶斯方法
Robert Dunne1, Roc Reguant2, Priya Ramarao-Milne2
1Data61, Commonwealth Scientific and Industrial Research Organisation, Sydney, Australia.
Computational and structural biotechnology journal
|September 15, 2023
概括
在随机森林 (RFs) 中,RFlocalfdr提供了一个更快,更准确的特征选择方法. 这种统计方法有效地识别重要特征,同时控制错误发现,即使是在大型数据集上.
科学领域:
- 计算生物学是一种计算生物学.
- 统计学学习 统计学学习
- 生物信息学是一种生物信息学.
背景情况:
- 随机森林 (RF) 很受欢迎,用于使用可变重要性测量 (VIM) 进行特征选择.
- 目前的VIM值方法对于高维数据来说是计算密集的.
- 需要一个强大的方法来控制RF特征选择中的假阳性.
研究的目的:
- 引入RFlocalfdr,这是一个新的统计方法,用于值RF平均降低不纯度 (MDI) VIMs.
- 在大型数据集中提供计算效率高的特征选择方法.
- 为了控制错误阳性率,同时识别显著特征.
主要方法:
- 根据Efron的经验贝叶斯框架开发了RFlocalfdr.
- 应用RFlocalfdr为RF模型的MDI进口门.
- 使用合成和现实世界的健康数据集进行验证,包括大规模的基因组学数据.
主要成果:
- RFlocalfdr的准确性与现有方法相提并论.
- RFlocalfdr比传统方法快了数量级.
- 成功地设置了一个数据集的门,数据点为10^6,证明了可扩展性.
结论:
- RFlocalfdr是用于RF特征选择的计算效率高,准确的工具.
- 它有效地控制了错误发现率,使其适合大规模的生物数据.
- 与各种RF实现兼容,增强其多功能性.
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