一个更新的系统性审查和对人类乳头瘤病毒在乳腺癌发生中的元分析
Usman Ayub Awan1,2, Aamer Ali Khattak2, Noman Ahmed2
1Medical Research Center, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Frontiers in oncology
|September 15, 2023
概括
人类乳腺瘤病毒 (HPV) 感染在全球25.6%的乳腺癌 (BC) 患者中流行. 这一系统性审查强调了HPV和乳腺癌之间的显著关联,需要进一步的机制性调查.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 乳腺癌 (BC) 是全球女性的主要恶性瘤.
- 人类乳头瘤病毒 (HPV) 感染被怀疑会影响BC病原性,但证据仍然不确.
研究的目的:
- 进行对乳腺癌患者HPV患病率的系统分析.
- 评估HPV感染与乳腺癌病因之间的关联.
主要方法:
- 从多个数据库中对74篇出版物 (1990-2022) 进行系统审查和随机效应元分析.
- 纳入标准集中在BC患者乳腺组织中的HPV流行率上.
- 进行了子组分析,以评估异质性和区域差异.
主要成果:
- 在7156个BC活检中,HPV的综合流行率为25.6%,具有显著的异质性.
- 病例控制研究显示,HPV患病率为26.2%,整体几率比为5.55.
- HPV-16是最常见的类型 (9.6%),欧洲报告了最高的区域患病率 (39.2%).
结论:
- 这项研究提供了对乳腺癌患者HPV患病率的全球估计.
- 已经证明HPV和乳腺癌病因之间存在显著的关联.
- 建议对潜在机制进行进一步的研究,以验证这些发现.
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