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在加拿大安大略省,对基于废水的监测进行季节性和规范化技术的评估

Hadi A Dhiyebi¹, Joud Abu Farah¹, Heather Ikert¹

¹Department of Biology, University of Waterloo, Waterloo, ON, Canada.

Frontiers in public health

|September 15, 2023

概括

针对COVID-19的废水监测发现,将SARS-CoV-2数据与PMMoV等便指标正常化并没有持续改善与临床病例的相关性. 特定地点的下水道特征会影响正常化策略的有效性.

科学领域:

环境微生物学环境微生物学
公共卫生监督是对公共卫生的监督.
病毒学病毒学

背景情况:

基于废水的监测 (WBS) 对于监测社区COVID-19流行率至关重要.
使用便指标的正常化在WBS中很常见,但对SARS-CoV-2的有效性需要进一步调查.

研究的目的:

评估病毒便指标胡轻斑病毒 (PMMoV) 的季节性.
评估利用PMMoV,crAssphage和流速来规范SARS-CoV-2废水数据的实用性,以改善与临床病例的相关性.

主要方法:

来自安大略省三个社区 (2021-2023) 的废水样本被分析为SARS-CoV-2,PMMoV和crAssphage.
季节-趋势-低压分解被用来分析PMMoV和流速季节性.
我们比较了正常化和非正常化SARS-CoV-2数据和临床病例之间的相关性.

主要成果:

PMMoV显示了夏季低谷的季节性趋势,但流量与PMMoV的相关性很差.
非正常化的SARS-CoV-2度与临床病例有很强的相关性 (r=0.620-0.854).
在两个位点,PMMoV正常化降低了相关性,而crAssphage和流量正常化与非正常化数据相比没有显著改善.

结论:

对SARS-CoV-2 WBS便指标正常化的有效性因地点和季节而异.
下水道的特点显著影响正常化效用,需要仔细考虑病毒生物标志物和正常化方法.

关键词:

这就是PMMoV的意义.这就是SARS-CoV-2病毒.在Crassphage中使用.便指标便指标规范化的正常化.季节性的季节性.

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