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氨基诺素氧化物:合成和对厌氧细菌的活性

Nadia Gruber1, Liliana Fernández-Canigia2, Natalia B Kilimciler1

  • 1Universidad de Buenos Aires, CONICET, Química Orgánica II, Departamento de Ciencias Químicas, Facultad de Farmacia y Bioquímica Junín 956 (1113) Buenos Aires Argentina lorelli@ffyb.uba.ar.

RSC advances
|September 15, 2023
PubMed
概括

新的阿米迪诺基诺素N-氧化物对厌氧细菌表现出强大的抗菌活性,显示出作为口服药物候选者的承诺. 这些化合物表现出与甲尼达可比的疗效,其中一些衍生物的效果优于参考药物.

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The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the...
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Direct alkylation of ammonia produces polyalkylated amines, along with a quaternary ammonium salt. To exclusively prepare primary amines, the azide synthesis method can be used.
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