在输血前检测中检测抗红细胞抗体的重要性
Svetlana Jovic Lackovic1, Sunita Delic Custendil1, Aida Zabic1
1Polyclinic for Transfusion Medicine, University Clinical Centre Tuzla, Tuzla, Bosnia and Hercegovina.
概括
输血治疗可能会导致抗体敏感化,导致严重反应. 在输血前检测期间识别抗红细胞抗体对于安全输血和预防不良事件至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 输血医学 输血医学
- 血液学 血液学 血液学
背景情况:
- 输血和怀孕可以导致抗体敏感化.
- 这种敏感性可能会导致中度至严重的输血后反应.
- 了解抗体概况是输血安全的关键.
研究的目的:
- 研究在接受输血前治疗的患者中抗红细胞抗体的特异性和频率.
- 根据患者的性别来确定这些抗体的来源.
- 评估已确定抗体的临床意义.
主要方法:
- 378个输血前抗体识别程序的回顾性分析.
- 数据从2018-2022年从输血综合诊所,UKC图兹拉收集的数据.
- 审查书面和电子患者文档.
主要成果:
- 在检测到的抗红细胞抗体中,Rh系统抗体最为普遍 (66.7%).
- 抗RhD抗体占32.4%,其次是抗Rh-E (20%) 和抗Rh-c (7.1%).
- 最常见的抗体组合是抗D和抗C (34.2%),以及抗E和抗c (21%).
结论:
- 输血前检测对于确保输血安全至关重要.
- 识别抗红细胞抗体可以降低输血后反应的风险.
- 利用表型化血液产品可以加强安全的血液政策.
更多相关视频
11:59Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
Published on: September 6, 2017
7.4K
11:27Prediction of Red Blood Cell Antibody Significance Using the Monocyte-Macrophage Assay
Published on: February 7, 2025
527
相关概念视频
Blood Typing
1.2K
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
1.2K
Rh Blood Group
1.5K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.5K
Blood Transfusion
603
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
603
Blood Transfusion and Agglutination
10.9K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.9K
The ABO Blood Group
1.8K
The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
1.8K
Blood Types
17.8K
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
17.8K
