皮下白色脂肪组织细胞组成和分子程序的变化是艾滋病毒感染者的葡萄糖不耐受症的基础
Samuel S Bailin1, Jonathan A Kropski2,3,4, Rama D Gangula5
1Department of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States.
Frontiers in immunology
|September 15, 2023
概括
皮下脂肪组织免疫细胞在艾滋病毒感染者 (PWH) 的代谢健康中起着关键作用. 这些细胞及其传播途径的变化与PWH中的葡萄糖不耐受和炎症有关.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢性疾病是一种代谢性疾病.
- 艾滋病毒研究 艾滋病毒研究
背景情况:
- 皮下脂肪组织 (SAT) 调节了新陈代谢的平衡.
- 艾滋病毒感染者 (PWH) 呈现改变的SAT免疫环境,并增加了代谢疾病的风险.
- 了解这些变化对于PWH代谢健康至关重要.
研究的目的:
- 创建一个全面的单细胞多原子图谱SAT.
- 在整个代谢健康谱中描述PWH的细胞和转录变化.
- 为了确定免疫细胞在PWH代谢功能障碍中的作用.
主要方法:
- 从59个PWH生成了一个单细胞多原子SAT图谱.
- 分析了细胞组成和基因表达.
- 进行了细胞间通信分析.
主要成果:
- 葡萄糖不耐受与增加的脂质相关巨细胞和T效应记忆细胞相关.
- 观察到炎症和脂质处理基因的丰富,随着葡萄糖不耐受性的增加.
- 增强了葡萄糖不耐受性PWH中免疫和肌肉细胞之间的亲炎和亲纤维信号传递.
- 与HIV阴性个体相比,糖尿病患者的PWH细胞间通信途径不同.
结论:
- 组织居民免疫细胞是PWH中SAT炎症的核心,具有代谢性疾病.
- 独特的机制有助于PWH中代谢疾病的发展.
- 在PWH代谢健康中,SAT免疫环境的改变至关重要.
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