自然杀手细胞和BNT162b2 mRNA疫苗的反应性和耐久性
Elizabeth K Graydon1,2, Tonia L Conner1, Kim Dunham3
1Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, United States.
Frontiers in immunology
|September 15, 2023
概括
自然杀手 (NK) 细胞在mRNA疫苗接种后激活,可能导致副作用. 接种疫苗前的NK细胞水平可能会影响抗体对Pfizer-BioNTech COVID-19疫苗的反应耐久性.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 自然杀手 (NK) 细胞调节免疫对疫苗接种的反应.
- 在mRNA疫苗接种几天后观察到NK细胞的激活.
研究的目的:
- 调查基线NK细胞特征和对瑞生物科技COVID-19疫苗 (BNT162b2) 的免疫反应之间的相关性.
- 评估NK细胞与疫苗诱导的炎症副作用之间的关系.
主要方法:
- 对188名医疗保健工作者血清和外周血液单核细胞 (PBMC) 的分析.
- 通过流细胞计量量化高峰特异性IgG抗体和NK细胞表型/频率的量化.
- 通过体外杀死试验评估炎症副作用和NK细胞功能.
主要成果:
- 在接种疫苗后一周内,NK细胞表现出激活.
- 疫苗接种前较高的NK细胞细胞毒性与第一剂后的症状得分增加相关.
- 基线NK细胞数量的增加与接种疫苗后六个月抗体水平的降低有关.
- 在不成熟的NK细胞上NKG2A的表达与增强的抗体反应相关.
结论:
- 通过BNT162b2疫苗接种激活NK细胞可能会导致炎症症状.
- 基线NK细胞特性可能会影响疫苗诱导的抗体反应的持久性.
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