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剪切波弹性图的价值在诊断和评估系统性硬化症中的价值

Ruyi Cai^1,2, Zhuohua Lin³, Dan Xu^1,2

¹Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China.

Rheumatology advances in practice

|September 15, 2023

概括

剪波弹性图 (SWE) 有效地评估系统性硬化 (SSc) 中的皮肤硬性,与疾病活动相关,并帮助诊断. 这种定量工具比监测SSc进展的传统方法更可靠.

科学领域:

类风湿病学类风湿病学
医疗成像医学成像
生物物理学的生物物理.

背景情况:

系统性硬化症 (SSc) 是一种复杂的自身免疫性疾病,其特征是皮肤变厚和纤维化.
准确评估皮肤硬度对于诊断和监测SSc.的疾病进展至关重要.
目前用于评估皮肤硬性的方法,例如修改后的罗丹皮肤评分 (mRSS),在客观性和可靠性方面存在局限性.

研究的目的:

评估剪切波弹性图 (SWE) 在量化SSc.患者的皮肤硬性的有效性.
确定SWE测量与SSc疾病活动的临床和组织学标志物之间的相关性.
评估SWE在区分SSc与SSc类疾病中的诊断价值,并将其灵敏度与现有的诊断标准进行比较.

主要方法:

剪切波弹性图 (SWE) 在66名SSc患者,100名健康对照者和27名SSc类疾病患者身上在17个修改的罗丹皮肤评分 (mRSS) 测量站点进行.
组之间比较了SWE值,并分析了与总mRSS的相关性,欧洲硬化皮肤研究小组疾病活动指数和组织学原沉积的相关性.
用接收器操作特征 (ROC) 曲线分析评估SSc的SWE诊断性能,并与1980年美国风湿病学会 (ACR) 标准进行比较.

主要成果:

在所有17个mRSS地点,SWE值在SSc患者中明显高于健康个体.
在SSc患者中,即使在临床上不涉及的皮肤部位 (mRSS=0) 中也观察到升高的SWE值.
SWE与总mRSS (r=0.783),疾病活性指数 (r=0.707) 和原沉积 (r=0.749) 显示出强烈的正相关性.
SWE有效地将SSc与SSc类疾病区分开来 (AUC=0.819),并且显示出明显高于1980年ACR标准 (81.8%与72.7%) 的灵敏度.

结论:

剪波弹性图是一种可靠的定量工具,用于评估系统性硬化症中的皮肤硬性和疾病活性.
SWE测量与SSc中的纤维化和疾病进展的临床和组织学指标有很好的相关性.
与传统方法相比,SWE提供了更好的诊断灵敏度和可靠性,有助于诊断和管理SSc.

关键词:

这就是为什么SSc SSc 剪波弹性图形剪波弹性图形皮肤病变皮肤病变

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