甲状腺相关眼病患者眼内压的眼外肌肉的预后值
Huiwen Tian1, Yu Wang2, Jing Li3
1Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Quantitative imaging in medicine and surgery
|September 15, 2023
概括
磁共振成像 (MRI) 对眼外肌肉 (EOM) 体积的测量可以帮助预测甲状腺相关眼科医症 (TAO) 患者的眼内压力 (IOP). 增加的EOM体积与更高的IOP有关,这表明甲基prednisolone治疗可能是有益的.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 放射学 放射学是一门学科.
背景情况:
- 甲状腺相关的眼病症 (TAO) 可以导致眼内压力 (IOP) 持续增加,导致不可逆转的视力损伤.
- 通过磁共振成像 (MRI) 测量的眼外肌肉 (EOM) 体积被研究为TAO患者IOP的预后因素.
研究的目的:
- 评估MRI测量EOM体积在预测TAO患者内血压升高的诊断价值.
- 评估EOM体积和其他轨道参数之间的相关性,包括视神经外皮直径和视网膜神经纤维层厚度.
- 为了确定甲基前尼索隆治疗对TAO患者EOM体积和IOP的影响.
主要方法:
- 一项追溯的横截面研究,涉及35名TAO患者的70只眼睛 (20个高IOP,50个正常IOP).
- 轨道MRI用于测量EOM体积,轨道脂肪,整个轨道体积,proptosis,视神经 (ON) 罩口直径,视神经角度 (ONA) 和视角.
- 光学连贯断层扫描 (OCT) 用于测量周状视网膜神经纤维层 (RNFL) 厚度.
- 统计分析包括t测试,奇平方测试,斯皮尔曼相关性,后勤回归和ROC曲线. 从20只眼睛获得的治疗前和治疗后的MRI数据使用对联t测试进行了比较.
主要成果:
- 与正常IOP组相比,高IOP组观察到显著增加的EOM体积和ONAs (P<0.001).
- 对于诊断高IOP (P=0.03),EOM体积显示出一个显著的切割值.
- EOM体积与ON罩口直径和平均RNFL厚度有显著的相关性 (P=0.01,P=0.02).
- 甲基普雷尼索隆治疗导致EOM体积和ON罩口直径显著减少,轴向ONAs增加 (P=0.002,P=0.02,P=0.05).
结论:
- 通过MRI测量EOM体积是监测TAO患者IOP变化和ON模式的有效诊断因素.
- 甲基prednisolone治疗是建议TAO患者的二次绿内障,以减少EOM体积和管理IOP.
相关概念视频
Accessory Structures of the Eye
1.6K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
1.6K
Open Angle Glaucoma: Treatment
477
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
477
Muscles of the Eye
1.4K
The muscles of the eye are sophisticated structures that control eye movement and focus, allowing for the precise and rapid adjustments necessary for vision. The human eye is controlled by ten muscles — six extraocular muscles, three intraocular muscles, and one primary eyelid retractor muscle.
Extraocular Muscles
The six extraocular muscles surround the eyeball and control its movements. They are responsible for a wide range of eye motions, including looking up, down, left, right, and...
Extraocular Muscles
The six extraocular muscles surround the eyeball and control its movements. They are responsible for a wide range of eye motions, including looking up, down, left, right, and...
1.4K
Glaucoma: Overview
618
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
618
Angle Closure Glaucoma: Treatment
559
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
559


