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甲状腺激素和矿物质在自身免疫性甲状腺疾病中疾病的免疫纠正中
Viktor Kravchenko1, Tamara Zakharchenko1
1Epidemiology of Endocrine Diseases, Vasily Pavlovich Komisarenko Institute of Endocrinology and Metabolism, Kyiv, Ukraine.
Frontiers in endocrinology
|September 15, 2023
概括
重要的矿物质和甲状腺激素会影响免疫功能和甲状腺健康. 营养不平衡可能导致自身免疫性甲状腺疾病 (AITD),强调需要有针对性的补充策略.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 甲状腺激素和必需的矿物质 (,,等) 对于免疫和甲状腺功能至关重要.
- 这些营养素的不平衡会破坏甲状腺激素,矿物质和免疫系统之间的相互作用,可能导致病理变化.
- 这种干扰与自身免疫性甲状腺疾病 (AITD) 的病原发生有关.
研究的目的:
- 审查甲状腺激素和矿物质的免疫调节作用.
- 检查它们在AITD病变发生过程中的参与,包括哈西莫托甲状腺炎和格雷夫斯病.
- 分析矿物质补充剂在AITD中的免疫校正潜力.
主要方法:
- 文献综述侧重于甲状腺激素,矿物质和免疫系统之间的相互作用.
- 分析矿物质过剩或不足在AITD发展中的作用.
- 检查AITD中的免疫介导机制,包括自身抗体和淋巴细胞透.
主要成果:
- 甲状腺炎的发病包括对甲状腺抗原和免疫媒介机制的免疫耐受性丧失.
- 调节性T细胞 (Treg),B细胞 (Breg),Th17/Treg细胞和细胞因子的失衡有助于AITD的进展.
- 氧化应激是AITD的一个重要因素,除了营养缺乏.
结论:
- 由于AITD缺乏有效的药理疗法,因此需要通过甲状腺激素和微量营养素探索免疫纠正.
- ,,和的食补充剂为AITD提供了潜在的治疗和预防策略.
- 需要对矿物质补充剂的免疫治疗应用进行进一步的批判性分析,以改善AITD管理.
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