鼻炎:一种罕见的机会主义感染
Saipriya Ayyar1, Rebekah Lantz2, Asif Khan3
1Boonshoft School of Medicine, Wright State University, Dayton, USA.
Cureus
|September 15, 2023
概括
一种具有挑战性的真菌感染Scedosporium鼻炎,在一个免疫力低下的HIV患者中,成功治疗了扩散性大B细胞淋巴瘤和血细胞淋巴组织细胞瘤. 手术除菌与沃里可纳结合解决了侵袭性真菌鼻炎.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 膜炎是免疫功能低下个体的机会性感染,通常对抗真菌药物有耐药性.
- 血液性恶性瘤和中性质衰竭增加了对Scedosporium无肺肺病的易感性.
- 侵袭性真菌鼻炎由于抗真菌耐药性而带来了重大治疗挑战.
研究的目的:
- 在免疫功能低下的患者中报告Scedosporium鼻炎病例.
- 描述这种罕见感染的诊断和治疗方法.
- 强调在复杂案件中多学科管理的重要性.
主要方法:
- 一名38岁的男性感染艾滋病毒,扩散性大B细胞淋巴瘤 (DLBCL) 和血细胞淋巴细胞瘤 (HLH) 呈现出面部疼痛和发烧.
- 面CT检测发现真菌性鼻炎;内透视透视形脱bridement证实了Scedosporium的生长.
- 外科干预包括脱bridement,大切除术和ethmoidectomy,然后是三个月的voriconazole疗程.
主要成果:
- 被诊断出由Scedosporium引起的真菌鼻炎.
- 患者成功完成了手术治疗和为期三个月的沃里可纳疗程.
- 感染消失了,患者在临床上在随访中表现良好.
结论:
- 积极的手术管理与适当的抗真菌疗法相结合,可以有效治疗Scedosporium鼻炎.
- 早期诊断和干预对于免疫受损患者的良好结果至关重要.
- 沃里科纳是Scedosporium鼻炎的有效治疗选择,需要对潜在的副作用进行监测.
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