在老年人中,短期和中期血压变化,认知和血管硬之间的横截面关联
D S Gutteridge1, P J Tully2, A E Smith3
1Cognitive Ageing and Impairment Neuroscience Laboratory (CAIN), University of South Australia, Adelaide, SA, Australia.
Cerebral circulation - cognition and behavior
|September 15, 2023
概括
高血压变化 (BPV) 在老年人中与较差的认知功能和增加的动脉硬性有关. 这表明BPV可能是认知能力下降的早期指标.
科学领域:
- 老年学是一门学科.
- 心血管健康 心血管健康
- 神经科学是一个神经科学.
背景情况:
- 高血压变化 (BPV) 是痴呆症的独立风险因素,特别是在老年人中.
- 了解BPV和认知障碍之间的关系对于早期检测和干预至关重要.
研究的目的:
- 调查各种血压变化 (BPV) 测量和认知功能之间的关联.
- 为了探索BPV与老年人血管硬之间的联系.
- 阐明BPV在认知障碍中的作用.
主要方法:
- 70名没有痴呆症的老年人 (60-80岁) 接受了认知测试.
- 使用24小时的门诊和4天的家庭血压监测来评估短期,中期和日常的血压.
- 测量了动脉硬度 (PWV) 和脑血管脉动性.
主要成果:
- 高缩和腹缩短期和中期BPV与较差的认知功能相关,独立于平均BP.
- 较高的短期BPV与注意力和精神运动速度的缺陷有关;日常BPV与执行功能有关.
- 系统性短期BPV与增加的动脉硬性相关;透静性日常BPV与降低的动脉硬性相关.
结论:
- 血压升高,无论平均血压如何,都与老年人认知能力下降和动脉硬性增加有关.
- 在老年人群中,BPV可能作为认知障碍的潜在早期临床标志物.
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