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vulvovaginal黑色素瘤的边际状态:50个病例的管理和瘤结果
Alli M Straubhar1, May P Chan2, Shitanshu Uppal1
1Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Michigan Medicine, 1500 E. Medical Center Dr., Ann Arbor, MI 48109, USA.
Gynecologic oncology reports
|September 15, 2023
概括
在手术边缘的先入侵性疾病会影响vulvovaginal黑色素瘤患者的局部复发. 早期 (第0期) 和晚期 (第3期) 疾病很少在局部复发,这表明重新切除可能对这些患者没有益处.
科学领域:
- 妇科瘤学 妇科瘤学
- 皮肤病学 皮肤病学
- 手术病理学手术病理学
背景情况:
- 性阴道黑色素瘤是一种罕见但具有攻击性的恶性瘤.
- 手术管理的目标是彻底去除瘤,但边缘状态对于预测结果至关重要.
- 侵袭前疾病在局部复发的边缘作用需要进一步澄清.
研究的目的:
- 调查边际状况,包括侵袭前疾病,对性阴道黑色素瘤局部复发和整体存活率 (OS) 的影响.
- 确定影响局部无进展生存 (PFS) 和OS的因素.
主要方法:
- 对50名经过手术治疗的 vulvovaginal 黑色素瘤 0-III 期患者 (2010-2019) 的回顾性分析.
- 边际状态被分类为负面,侵袭前疾病或侵袭性黑色素瘤.
- 用于评估PFS和OS的卡普兰-梅尔和考克斯回归分析.
主要成果:
- 46%的患者在边缘出现了侵袭前疾病;44%的患者有负边缘.
- 五年当地PFS为63%,OS为60%.
- 年龄,深度,阶段,边缘状态和再切割并没有显著影响本地PFS. 在侵袭前边缘病例中,局部复发发生在I-II阶段的疾病中.
结论:
- 在外科手术边缘的先入侵性疾病可能是I-II阶段性阴道黑色素瘤局部复发的重要因素.
- 患有0期和III期疾病的患者表现出较低的局部复发率,可能不会从重新切除中受益.
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