长途COVID-19患者嗅觉功能障碍的特征
Meredith M Lamb1, Kaitlyn DeHority2, Sarah M Russel1
1Department of Otolaryngology - Head and Neck Surgery, The University of North Carolina, Chapel Hill, NC.
概括
长途COVID-19经常导致持续的嗅觉功能障碍 (OD),影响近85%的患者. 然而,这种长期COVID症状的严重程度与特定的SARS-CoV-2变种无关.
科学领域:
- 传染性疾病 传染性疾病
- 神经学 神经学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 长途COVID-19的特点是症状持续超过三个月,影响了大量患者.
- 嗅觉功能障碍 (OD) 是一个普遍的长期COVID症状,在感染后的一年内发生的病例高达63.5%.
- 最初的SARS-CoV-2变体与长途OD的发展/严重性之间的关系仍然不太清楚.
研究的目的:
- 调查长途COVID-19患者嗅觉功能障碍的患病率和严重程度.
- 为了确定长途COVID-19患者的OD严重程度是否与他们最初感染期间的主导的特定SARS-CoV-2变种相关.
主要方法:
- 被诊断为长途COVID-19的患者从一个专门的康复诊所招募.
- 用宾夕法尼亚大学的气味识别测试 (UPSIT) 来评估嗅觉功能障碍.
- 感染时的主要SARS-CoV-2变种是使用诊断日期和公共卫生数据库识别的.
主要成果:
- 近85%的长途COVID-19患者报告了某种程度的持续嗅觉功能障碍.
- 嗅觉功能障碍在一些患者中持续长达两年,症状持续时间和严重程度之间没有发现关联.
- 根据感染时的主导SARS-CoV-2变种,没有观察到OD严重程度的统计学上显著差异.
结论:
- 持续的嗅觉并发症在长途COVID-19患者中非常普遍.
- 长途COVID-19中嗅觉功能障碍的严重程度不受初始感染期间遇到的特定SARS-CoV-2变种的影响.
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