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不同的肠道微生物群,便秘患者的饮食摄入量 患有或没有高血压的患者
Junqi Li1, Guoqing Ma1, Jiawen Xie1
1Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, China.
Molecular nutrition & food research
|September 15, 2023
概括
便秘患者的高血压与肠道微生物群的差异有关. 吃干豆可能会降低血压,肠道微生物Monoglobus可能会调解.
科学领域:
- 微生物学 微生物学
- 心血管健康 心血管健康
- 胃肠病学 胃肠病学
背景情况:
- 饮食和肠道微生物群在血压调节中发挥作用.
- 关于便秘患者的这些因素的研究有限.
研究的目的:
- 确定便秘的高血压和正常血压个体之间的肠道微生物群差异.
- 分析饮食模式与血压的关系.
- 探索肠道微生物群的潜在调解效应.
主要方法:
- 对于186名功能性便秘参与者,使用了16S rRNA测序和食物频率问卷.
- 在高血压和正常血压组之间比较了肠道微生物多样性 (α和β) 和差异性属.
- 饮食摄入量,特别是干豆,与血压相关,后勤回归评估了高血压风险.
主要成果:
- 与高血压患者相比,高血压患者表现出下肠道微生物的α和β多样性 (p<0.05) 和17个不同的属性.
- 干豆摄入量与静缩和静缩血压呈反相关性 (p-FDR < 0.01和p-FDR = 0.026,分别).
- 经常食用干豆的人患高血压的风险明显降低 (OR = 0.137,p = 0.022).
结论:
- 不同的肠道微生物特征与功能性便秘患者的高血压有关.
- 增加干豆的消费与降低血压和降低高血压风险有关.
- 肠道属Monoglobus可能部分调解高纤维饮食和高血压之间的关系.
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