[肥胖,2型糖尿病和抑郁症:抗抑郁药对代谢有什么影响?]
André Scheen1,2
1Service de Diabétologie, Nutrition et Maladies métaboliques, Département de Médecine, CHU Liège, Belgique.
Revue medicale de Liege
|September 15, 2023
概括
抗抑郁药可以导致代谢障碍,如失糖症和失脂症,需要仔细监测. 虽然风险低于某些抗精神病药物,但它仍然存在.
科学领域:
- 药理学和内分泌学 药理学和内分泌学
- 精神病学是一个精神病学.
- 代谢健康 代谢健康
背景情况:
- 代谢障碍,包括失糖症,失脂症和代谢综合征,是抗抑郁药使用的潜在不良影响.
- 精神病患者经常表现出生活方式因素 (饮食不良,久坐) 和药物不服药,增加代谢和心血管风险.
研究的目的:
- 审查与抗抑郁药物相关的代谢障碍的发生和管理.
- 强调在临床实践中考虑代谢风险的重要性,尽管不同类药物之间存在不同的风险.
主要方法:
- 对抗抑郁药诱导的代谢副作用研究的文献综述.
- 分析与选择性血清素再吸收抑制剂 (SSRI) 和三环抗抑郁药 (TCA) 相关的代谢风险.
- 考虑混因素,如生活方式和药物遵守.
主要成果:
- 代谢障碍可以发生在SSRI和TCA两种类型中,每个类别内的分子间变化.
- 虽然抗抑郁药的代谢风险通常低于非典型抗精神病药,但抗抑郁药的代谢风险,特别是那些导致体重增加的药物,需要临床关注.
- 生活方式因素和不良坚持显著导致精神病患者的代谢并发症.
结论:
- 与抗抑郁药物相关的个体代谢风险是复杂的确定由于多种因素.
- 有效的抑郁症管理可以改善生活方式的坚持和整体生活质量,间接地减轻代谢风险.
- 处方抗抑郁药时,对代谢变化的临床警至关重要,特别是与体重增加相关的抗抑郁药.
更多相关视频
06:55An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
22.6K
06:28A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
Published on: April 28, 2023
868
相关概念视频
Antidepressant Drugs: MAOIs and Other Agents
270
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
270
Antidepressant Drugs: Overview
555
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
555
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
431
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
431
Oral Hypoglycemic Agents: Biguanides and Glitazones
230
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
230
Carbohydrate Metabolism
11.2K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.2K
Obesity
534
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
534
