[基于的纳米颗粒用于胃肠癌的化学动力疗法]
1Department of Spleen and Stomach Diseases, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510515, China.
Nan fang yi ke da xue xue bao = Journal of Southern Medical University
|September 15, 2023
概括
含有葡萄糖氧化酶 (MSN@Mn-GOx) 的基半孔纳米颗粒通过增强活性氧物种的产生和抑制癌细胞增殖,对胃肠癌产生强大的抗瘤作用.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 材料科学 材料科学 材料科学
背景情况:
- 胃肠道癌症是一个重大的全球健康挑战.
- 开发新的治疗策略对于改善患者的治疗结果至关重要.
研究的目的:
- 为了合成和表征含有葡萄糖氧化酶载荷的基于的半孔性二氧化纳米颗粒 (MSN@Mn-GOx).
- 为了评估MSN@Mn-GOx对胃肠道癌症的抗瘤疗效.
- 调查潜在的作用机制,包括反应性氧物种 (ROS) 生成和化学动力学特性.
主要方法:
- 使用TEM,DLS,Zeta潜力,UV-Vis,EDS和XPS进行纳米粒子表征.
- 为体内研究建立人类结肠癌HT-29异种移植小鼠模型.
- 使用MRI成像,ROS生产试验,CCK-8和EDU试验评估抗瘤效应.
主要成果:
- MSN@Mn-GOx纳米粒子是大小均的球体 (~100nm) 具有负Zeta电位 (-35mV).
- 这些纳米粒子表现出增强的H2O2催化效率和芬顿式特性,特别是在较低的pH值 (6.0) 时.
- 在体内研究显示,瘤中T1加权的MRI信号的剂量依赖增强和显著抑制胃癌和结肠癌细胞增殖,并增加ROS水平.
结论:
- MSN@Mn-GOx纳米粒子具有有利的化学动力学特性.
- 它们对抗胃肠道癌症具有显著的抗瘤活性.
- 这些纳米粒子代表了胃癌治疗的有希望的治疗候选者.
相关概念视频
Drugs that Stabilize Microtubules
2.1K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.1K
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
190
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
190
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Drugs that Destabilize Microtubules
2.0K
Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
2.0K


