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网症:塑造瘤转移和免疫疗法

Yanyan Hu¹, Houhong Wang², Yang Liu³

¹Department of Digestive Diseases 1, Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Institute, Shenyang, China.

Immunological reviews

|September 15, 2023

概括

中性细胞细胞外陷 (NETs) 通过保护瘤细胞并帮助它们扩散,促进癌症转移. 向NETosis可能会提高癌症免疫治疗在转移性疾病中的有效性.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
细胞生物学细胞生物学

背景情况:

中性细胞细胞外陷 (NETs) 参与免疫反应,并与癌症进展有关.
NETosis,NET形成的过程,在瘤微环境 (TME) 中起着至关重要的作用.

研究的目的:

审查NETosis在不同阶段对瘤转移的多方面的影响.
突出了解NETosis-TME相互作用对于开发新型癌症免疫疗法的重要性.

主要方法:

文献综述侧重于NETosis在癌症转移中的作用.
在瘤微环境和免疫治疗的背景下对NETosis进行研究的研究分析.

主要成果:

NETs保护瘤细胞免受免疫监测,阻碍瘤的清除.
NETs促进瘤细胞的血管内传播和传播到遥远的器官.
向NETosis在改善癌症免疫疗法的有效性方面显示出希望.

结论:

NETosis通过影响免疫逃避和传播,显著促进瘤转移.
了解NETosis和TME组件之间的相互作用对于设计有效的组合免疫疗法至关重要.
向NETosis提供了一个潜在的策略,以提高转移性癌症患者的治疗结果.

关键词:

网症 (NETosis) 是一种疾病.免疫疗法免疫疗法转移转移转移转移中性粒细胞外细胞陷瘤微环境是一个微环境.

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