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Updated: Jul 16, 2025

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
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Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model

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应用一种基于生理学的药理动力学模型来预测怀孕期间的异化物处置

Ogochukwu U Amaeze1, Nina Isoherranen1

  • 1Department of Pharmaceutics, University of Washington, School of Pharmacy, Seattle, Washington, USA.

Clinical and translational science
|September 15, 2023
PubMed
概括

怀孕通过增加其他清除途径而不是N-乙转移酶2 (NAT2) 活性而改变异化 (INH) 药理学. 这一发现对于优化孕妇结核病预防至关重要.

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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

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Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

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