柏柏林-脂纳米聚合物嵌入的硫化奇托水凝用于口腔炎治疗口腔炎
Yasaman Hashtrodylar1, Shahram Rabbani2, Simin Dadashzadeh1
1Department of Pharmaceutics & Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, 1996835113, Tehran, Iran.
Nanomedicine (London, England)
|September 15, 2023
概括
这项研究开发了一种含有柏柏林-脂纳米聚合物的新型硫化奇托水凝,用于治疗口腔炎. 这种新配方在体内表现出增强的粘膜粘附和优越的治疗效果.
科学领域:
- 药理学 药理学是指药理学的学科.
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 口腔口腔炎是一种常见的口腔炎症状况.
- 目前的治疗方法在有效性和停留时间上可能有局限性.
- 柏柏林显示抗炎性质,但需要有效的输送系统.
研究的目的:
- 开发和评估一种用于治疗口腔炎的新型药物输送系统.
- 为了创建纳米聚合物的柏柏林-脂复合物纳入化基酸盐 (TCS) 水凝.
- 评估纳米聚合物-TCS水凝的体外和体内性能.
主要方法:
- 通过溶剂蒸发和组装成纳米聚合物的柏柏林-脂复合物的配方.
- 通过将硫糖酸连接到基托 (CS) 来合成硫化基托 (TCS).
- 纳米聚合物-TCS水凝的制备和通过体外和体外研究进行评估.
主要成果:
- 纳米聚合物-TCS水凝证明了柏柏林的长时间释放.
- 纳米聚合物-TCS的粘膜粘合强度是CS水凝的1.75倍.
- 在体内研究证实了纳米聚合物-TCS的优越疗效.
结论:
- 纳米聚合物-TCS水凝提供延长药物释放和增强粘膜粘合.
- 该系统表现出显著的抗炎作用,导致卓越的治疗结果.
- 纳米聚合物-TCS是一种有前途且有效的治疗口腔炎治疗系统.
相关概念视频
01:26Peptic Ulcer Disease IV: Management
110
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
110
01:24Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
544
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
544