系统性红斑狼的生物标志物 - 关注器官损伤
Huihua Ding1,2, Yiwei Shen1,2, Soon-Min Hong1,2
1Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.
Expert review of clinical immunology
|September 15, 2023
概括
确定系统性红斑狼 (SLE) 的可靠生物标志物对于诊断,监测和治疗至关重要. 虽然对于皮肤,脏和神经系统的参与存在有前途的生物标志物,但尚未在常规临床使用中.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 生物标志物发现发现
背景情况:
- 系统性红斑狼 (SLE) 是一种复杂的自身免疫性疾病,表现不同,进展不可预测.
- 有效管理SLE需要可靠的生物标志物用于早期诊断,疾病活动监测和治疗反应评估.
研究的目的:
- 审查用于诊断和监测SLE的新兴生物标志物,重点关注常见受影响的器官:皮肤,脏和神经系统.
- 总结表明在评估SLE疾病活性和治疗疗效方面有希望的生物标志物.
主要方法:
- 文献综述侧重于SLE中的生物标志物.
- 对皮肤,脏和神经系统参与SLE相关的生物标志物的分析.
- 对SLE的诊断和预后生物标志物进行当前研究的综合.
主要成果:
- 已经确定了几种有前途的生物标志物,用于SLE中特定器官的参与.
- 尽管取得了进展,但没有一个生物标志物被验证用于SLE管理中的常规临床应用.
- 生物标志物研究面临挑战,包括SLE异质性和需要大规模验证.
结论:
- 新型生物标志物具有显著的潜力,可以在SLE中推进精密医学.
- 经过验证的生物标志物可以个性化治疗策略,改善SLE患者的治疗结果.
- 需要进一步的研究来克服挑战,并将生物标志物发现转化为SLE的临床实践.
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
118
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
118
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
200
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
200
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
38
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
38