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在永久牙中非感染相关的炎症性根部再吸收的致病性:叙述性综述
Shaul Lin1,2,3, Athina M Marvidou4, Rostislav Novak3,5
1The Israeli National Center for Trauma & Emergency Medicine Research, Gertner Institute, Tel Hashomer, Israel.
International endodontic journal
|September 15, 2023
概括
永久牙中的根吸收可能与感染无关,由无菌损伤和激活免疫细胞引发. 这一过程在伤口愈合过程中发生,可以导致根部再吸收作为副作用.
科学领域:
- 牙科 牙科是指牙科的专业.
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
背景情况:
- 永久牙的根部再吸收被分为与感染有关的或与感染无关的.
- 非感染相关的再吸收包括无菌损伤和明显的免疫系统刺激.
- 了解这些机制对于牙健康至关重要.
研究的目的:
- 描述永久牙根再吸收中非感染相关的炎症过程的病理生理学.
- 阐明涉及的细胞和分子机制.
主要方法:
- 进行了文学叙事审查.
- 这些搜索包括Scopus,PubMed,Medline和谷歌学者.
- 分析了相关的体外,体内研究,评论和教科书.
主要成果:
- 三种与感染无关的再吸收类型:表面再吸收 (创伤/正牙力),外部置换再吸收和外部宫再吸收.
- 触发因素包括损伤相关分子模式 (DAMPs) 和缺氧.
- 巨细胞和状细胞清除受损的组织和骨,启动修复.
结论:
- 根吸收发生在伤口愈合的炎症阶段.
- 免疫细胞 (巨细胞,中性粒细胞) 分泌细胞因子 (TNF-α,IL-1,IL-6,IL-8).
- 低氧会加速生长因子的分泌,启动修复;对水泥/水泥细胞的损伤会导致再吸收.
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