睡眠呼吸暂停,肠道疾病和认知功能障碍
Tenzin Deyang1, Md Awaise Iqbal Baig1, Phurbu Dolkar1
1Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, India.
The FEBS journal
|September 15, 2023
概括
肠道疾病,肠道细菌的不平衡,与睡眠呼吸暂停有关. 用益生菌和益生菌恢复肠道健康可能会改善睡眠呼吸暂停和相关的认知问题.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
背景情况:
- 睡眠障碍很普遍,影响身体和精神健康.
- 在睡眠障碍中观察到肠道失调 (GD),睡眠呼吸暂停是由于其患病率而引起的重大关注.
- 现有研究表明,睡眠呼吸暂停和GD之间存在联系.
研究的目的:
- 审查肠-大脑轴与睡眠呼吸暂停和肠道失调有关.
- 讨论肠道微生物群及其代谢物在睡眠呼吸暂停病理生理学的作用.
- 检查益生菌和益生菌在治疗睡眠呼吸暂停及其并发症方面的潜力.
主要方法:
- 临床前和临床研究的文献综述.
- 对肠-大脑通信通路的分析.
- 检查肠道失调对睡眠呼吸暂停和认知功能的影响.
主要成果:
- 肠-大脑轴涉及微生物代谢物,神经递质,免疫细胞和HPA轴.
- 肠道疾病和改变的肠道细菌有助于睡眠呼吸暂停和认知功能障碍.
- 益生菌和益生菌显示出恢复肠道平衡和改善睡眠呼吸暂停结果的潜力.
结论:
- 肠道功能障碍在睡眠呼吸暂停和相关的认知障碍中起着病理作用.
- 通过益生菌和益生菌调节肠道微生物群可能为睡眠呼吸暂停提供治疗益处.
- 准肠-大脑轴为管理睡眠呼吸暂停及其并发症提供了一个有希望的途径.
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