在无活化SARS-CoV-2疫苗接种后,IgA脏病的脏结局
Ke Sun1, Da Shang1, Chuanming Hao1
1Division of Nephrology, Huashan Hospital, Fudan University, No. 12 Wulumuqi Middle Road, Shanghai, 200040, China.
Clinical and experimental nephrology
|September 15, 2023
概括
在接种SARS-CoV-2疫苗后,IgA脏病 (IgAN) 患者经历了轻微的,暂时的功能下降,特别是那些有先前存在的脏问题的人. 需要进一步的研究来评估长期影响.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 越来越多的报道将SARS-CoV-2疫苗与IgA病 (IgAN) 爆发联系起来.
- 关于IgAN患者在接种疫苗后的结局的数据有限.
- 这项研究侧重于非活化SARS-CoV-2疫苗.
研究的目的:
- 为了评估IgA脏病患者在无活化SARS-CoV-2疫苗接种后的结局.
- 为了确定疫苗接种后蛋白尿症恶化的预测因素.
- 为了比较接种疫苗和未接种疫苗的Igan患者之间的结局.
主要方法:
- 在接种疫苗后的113名Igan患者中,评估了估计的淋巴细胞过率 (eGFR),蛋白尿和血尿的变化.
- 蛋白尿症恶化定义为>0.5倍增加和>1g/d.
- 利用后勤回归并将6个月的结果与101个未接种疫苗的对照进行了比较.
主要成果:
- 在接种疫苗后观察到功能下降2.54%.
- 在中度功能障碍 (30 ≤ eGFR < 60) 的患者中,第二剂后观察到显著的EGFR下降.
- 10名患者出现了暂时恶化的蛋白尿症,在6个月内改善.
- 较高的基线eGFR是防止蛋白尿症恶化的保护因素.
结论:
- 接种SARS-CoV-2疫苗可能导致IgA脏病患者功能暂时恶化.
- 最初功能较差的患者更容易受到这些影响.
- 观察到的影响似乎在临床上是轻微的,需要进一步调查长期后果.
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