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中国孕妇血清度的参考间隔

Yi Wu¹, Huan-Huan Long¹, Su-Juan Zhang¹

¹Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University (North Campus), Guangzhou, 510080, People's Republic of China.

Biological trace element research

|September 15, 2023

概括

这项研究为中国孕妇建立了三个月特定的血清 (SI) 参考范围. 怀孕早期母亲的SI与母亲的甲状腺功能有关,并且比尿液更好地预测甲状腺状况.

科学领域:

内分泌学在内分泌学.
公共卫生公共卫生
营养科学营养科学

背景情况:

对于甲状腺激素的合成至关重要,对母亲和胎儿的健康至关重要.
在怀孕期间确定准确的状态参考范围对于监测和干预至关重要.
现有的参考范围可能无法普遍适用,需要特定人群的数据.

研究的目的:

为了确定中国孕妇血清 (SI) 的三个月具体参考范围.
研究母亲血清水平与母亲/婴儿甲状腺功能之间的关联.
为了评估血清与尿液对甲状腺疾病的预测能力.

主要方法:

从健康的孕妇收集血清和尿液样本,以使用ICP-MS确定水平.
测量了母亲的甲状腺功能 (FT3,FT4,TSH) 和新生儿的TSH.
使用了季度特定的SI参考范围 (2.5至97.5百分位数) 和ROC分析.

主要成果:

建立了三个月特定的SI参考范围:T1 (60.91-114.53微克/L),T2 (54.57-103.42微克/L),T3 (52.03-110.40微克/L).
怀孕第一季度母亲的SI与FT3,FT4和TSH有显著的相关性.
孕产妇的SI在甲状腺状况方面表现出较高的可预测性,与尿标志物相比.

结论:

该研究为中国孕妇提供了三个月的血清基准值范围.
孕妇的血清水平与怀孕期间的甲状腺激素状况密切相关.
血清是评估状态和预测怀孕期间甲状腺功能障碍的宝贵生物标志物.

关键词:

怀孕怀孕怀孕怀孕孕妇的甲状腺功能孕妇的甲状腺功能胡安·胡安·龙女士作为第一作者对手稿做出了类似的贡献.参考间隔的参考间隔.血清中的.

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