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对肺的内部目标体积定义的不确定性进行调查 立体性身体放射疗法
Daiki Nakanishi1,2, Masataka Oita3, Jun-Ichi Fukunaga1
1Division of Radiology, Department of Medical Technology, Kyushu University Hospital, 3-1-1, Maidashi Higashi-Ku, Fukuoka, 812-8582, Japan.
Radiological physics and technology
|September 15, 2023
概括
与三维CT相比,四维计算机断层扫描 (4DCT) 在立体体辐射疗法 (SBRT) 期间为肺瘤提供了优越的内部目标体积 (ITV) 覆盖. 这种方法提高了自由呼吸的上叶肺癌患者的治疗精度.
科学领域:
- 辐射瘤学 辐射瘤学
- 医疗成像医学成像
- 胸部外科手术 胸部外科手术
背景情况:
- 准确的内部目标体积 (ITV) 定义对于有效的立体性身体放射疗法 (SBRT) 是至关重要的.
- 在自由呼吸期间的瘤运动在辐射向方面提出了挑战,特别是在肺部瘤中.
研究的目的:
- 评估通过三维计算机断层扫描 (3DCT) 和4DCT定义的ITV的准确性.
- 为了将这些ITV与SBRT期间的实际瘤运动进行比较,用于上叶肺瘤.
主要方法:
- 对接受SBRT的五名上叶肺瘤患者的回顾性分析.
- 获得计划3DCT (峰值呼气,峰值吸气) 和4DCT (cine模式,自由呼吸).
- 使用电影图像评估瘤覆盖范围,并比较3DCT-ITV与4DCT-ITV在头骨-尾尾,左右和前后后方向.
主要成果:
- 基于四维计算机断层扫描 (4DCT) 的ITV显示,与基于3DCT的ITV相比,骨-尾尾方向的瘤覆盖率更高.
- 该研究强调了在使用4DCT用于治疗计划时需要内部边际.
- 基于4DCT的ITV被提出为上叶肺瘤自由呼吸SBRT的有效方法.
结论:
- 四维计算机断层扫描 (4DCT) 为肺SBRT提供了更好的内部目标体积 (ITV) 定义.
- 4DCT方法提高了瘤覆盖率,从而对上叶肺部瘤进行潜在的更有效的治疗.
- 在SBRT规划中实施基于4DCT的ITV时,考虑内部利是必不可少的.
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