关于脱二三酸盐 (DHEAS) 的规范性数据及其在健康的印度儿童和青少年中的属性
Bhanu Malhotra1, K V Ravi Teja1, Shariq R Masoodi2
1Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.
Indian journal of pediatrics
|September 15, 2023
概括
脱水氨硫酸 (DHEAS) 水平对于评估印度儿童的青春期至关重要. 这项研究建立了参考范围,并确定了影响DHEAS水平的关键因素,如骨龄和BMI.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生殖生物学 生殖生物学
- 生物化学 生物化学
背景情况:
- 脱乙硫酸 (DHEAS) 是上腺和 pubarche 的一个关键指标.
- 准确的DHEAS参考范围对于诊断青春期相关疾病至关重要.
- 现有的DHEAS范围需要特定于种族,年龄,性别和Tanner阶段.
研究的目的:
- 为了确定印度儿童血清DHEAS的种族,年龄,性别和Tanner阶段特定的参考范围.
- 为了确定最佳的DHEAS切断水平来识别 pubarche.
- 研究DHEAS与人体测量,骨龄和荷尔蒙参数的相关性.
主要方法:
- 对2191名5-18岁健康的印度儿童进行了查.
- 用DHEAS的电化学发光试验进行荷尔蒙分析.
- 通过BoneXpert软件估计骨龄.
- 接收器操作特征 (ROC) 曲线分析用于DHEAS截止值的确定.
主要成果:
- 在坦纳阶段P2的DHEAS水平中位数为女孩的82.10g/dl,男孩的132.50g/dl.
- 在ROC分析中发现,在青春期,女孩的DHEAS切割值为63.7g/dl,男孩的DHEAS切割值为82.2g/dl.
- 上腺的平均年龄在两性中均为9.5岁.
- 骨年龄,BMI,淋巴腺类固醇和IGF-1与DHEAS水平显著相关.
结论:
- 为印度儿童建立了特定的DHEAS参考范围,这对于准确的青春期评估至关重要.
- 确定了DHEAS水平与骨年龄,BMI,淋巴腺类固醇和IGF-1之间的显著相关性.
- 强调在儿童内分泌学中对DHEAS进行全面评估时考虑多个因素的重要性.
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