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益生菌对胰腺β细胞功能在2型糖尿病:一个随机,双盲,安慰剂控制的临床试验
Maryana Savytska1, Dmytro Kyriienko2, Iuliia Komisarenko3
1Normal Physiology Department, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.
概括
益生菌补充剂在2型糖尿病患者中适度改善了胰腺β细胞功能和血糖控制. 这种肠道微生物群调节为糖尿病治疗提供了潜在的新途径.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 代谢研究研究 代谢研究
背景情况:
- 益生菌在与胰岛素抵抗相关的代谢障碍中表现出有效性.
- 益生菌对胰腺β细胞功能在2型糖尿病 (T2D) 的影响仍然不清楚.
- 这项研究调查了益生菌补充剂对T2D患者β细胞功能的影响.
研究的目的:
- 评估活多菌株益生菌与安慰剂对T2D患者β细胞功能的影响.
- 为了评估血糖控制,人类测量变量和细胞因子水平的变化.
- 为了确定益生菌治疗是否可以调节T2D的慢性系统性炎症.
主要方法:
- 这是一项双盲,随机,安慰剂对照试验,涉及68名T2D患者.
- 参与者服用活多菌株益生菌或安慰剂8周.
- 主要结果:C-和恒常模式评估估计的β细胞功能 (HOMA-β) 的变化;次要结果:血糖控制,人类测量和细胞因子.
主要成果:
- 益生菌补充导致β细胞功能显著改善 (HOMA-β增加;p=0.003).
- 与安慰剂相比,观察到空腹葡萄糖水平 (p<0.001) 和HbA1c (p=0.043) 的显著降低.
- 益生菌治疗显著降低了促炎性细胞因子水平,表明对慢性系统性炎症有影响.
结论:
- 益生菌疗法在T2D患者的胰腺β细胞功能中提供了适度的改善.
- 调节肠道微生物群为糖尿病管理提供了一个新的治疗策略.
- 需要进一步的广泛研究来证实这些发现,并探索更广泛的应用.
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