在Crotonis Fructus诱导的小鼠肠道微生物群和血清代谢障碍
Jiali Wang1, Zefei Jia1, Wen Pan1
1School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, Tianjin, 301617, China.
Applied microbiology and biotechnology
|September 15, 2023
概括
克罗托尼斯果实 (CF) 通过改变肠道微生物群和破坏葡萄糖脂代谢,导致肝脏和胃肠道受损. 这项研究揭示了CF.
科学领域:
- 毒理学 毒理学 毒理学
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
背景情况:
- 克罗托尼斯果实 (CF) 是一种传统的药,有着悠久的使用历史.
- 尽管其有效,CF的毒性和潜在机制仍然不太清楚.
- 调查CF的毒理特征对于安全的临床应用至关重要.
研究的目的:
- 为了阐明Crotonis Fructus的毒理影响.
- 通过分析肠道微生物群和血清代谢物来研究CF毒性的机制.
- 建立肠道失调,代谢干扰和CF诱导的毒性之间的联系.
主要方法:
- 高通量16S rDNA测序用于肠道微生物群分析.
- 不针对的血清代谢组分用于代谢物概况.
- 肝脏和胃肠组织的组织病理学检查.
主要成果:
- 在老鼠中,CF引发了显著的肝脏和胃肠道损伤.
- 结核病治疗导致肠道微生物群失生,增加机会性病原体,减少像乳酸菌这样的有益细菌.
- 代谢学揭示了甘油脂代谢的干扰,酸胆和酸乙烯胺的水平发生了变化.
结论:
- 克罗托尼斯果实通过肠道微生物群的改变和代谢障碍产生毒性.
- 甘油脂代谢是受CF毒性影响的关键途径.
- 了解这些机制为安全使用有毒传统药物提供了洞察力.
相关概念视频
01:18Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
01:21Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...