便秘与任何严重程度的抑郁症有关,但与自杀念头无关:来自一项大型横截面研究的见解
Yan Wang1, Xia Shen2, Pengfei Wang3
1Department of Oncology, China Academy of Chinese Medical Sciences Guang' Anmen Hospital, Beijing, 100053, China.
International journal of colorectal disease
|September 15, 2023
概括
便秘与美国成年人,特别是男性的抑郁症有着显著的联系. 然而,这项研究发现便秘和自杀念头 (SI) 之间没有显著的关联.
科学领域:
- 医学研究 医学研究
- 精神病学是一个精神病学.
- 胃肠病学 胃肠病学
背景情况:
- 便秘和精神健康状况 (如抑郁症和自杀念头) 之间的关系需要进一步调查.
- 现有的研究还没有充分探讨一般成年人群中的这种关联.
研究的目的:
- 调查便秘与美国成年人中抑郁症或SI的患病率之间的联系.
- 为了确定便秘是否是抑郁症或SI的危险因素.
主要方法:
- 利用来自美国国家健康和营养检查调查 (2009-2010) 的4,562名美国成年人 (20岁以上) 的数据.
- 使用肠道健康问卷评估便秘.
- 使用患者健康问卷-9 (PHQ-9) 测量抑郁症和SI.
- 采用多变量逻辑回归来计算调整的赔率比率 (ORs),并进行子组分析以验证结果.
主要成果:
- 在对共变量进行调整后,便秘与整体抑郁评分 (OR:1.13,95%CI:1.10-1.16) 和临床抑郁症 (OR:3.76,95%CI:2.65-5.34) 有显著的关联.
- 观察到一种剂量反应关系,较高的抑郁症严重程度与更强烈的便秘相关 (轻度:OR 2.21,中度:OR 3.69,严重:OR 6.84).
- 便秘和SI之间的关联在统计上没有显著性 (OR: 1.36,95%CI: 0.78-2.37).
- 与女性相比,男性的便秘与抑郁症的相关性更强.
结论:
- 在美国成年人中,便秘与所有严重程度的抑郁症有显著的关联.
- 便秘和自杀念头之间没有发现显著的关联.
- 医疗保健提供者应考虑便秘患者的心理健康,特别是男性,因为与抑郁症有很强的联系.
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