基于部门的回归策略,以减少折射误差相关的玻璃眼诊断偏差在使用OCT和OCT血管学时
Keke Liu1,2, Qi Sheng You1, Aiyin Chen1
1Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA.
Translational vision science & technology
|September 15, 2023
概括
对光连贯断层扫描 (OCT) 和OCT血管学 (OCTA) 的部门分析显示,折射误差影响诊断参数. 对轴长和球形等效的特定行业调整减少了对青光眼的检测中错误的阳性结果.
科学领域:
- 眼科医生 眼科 眼科
- 医疗成像医学成像
- 青光眼的诊断 青光眼的诊断
背景情况:
- 折射误差,包括近视和远视,可以影响光学连贯断层扫描 (OCT) 和OCT血管学 (OCTA) 的测量.
- 准确的青光眼诊断依赖于精确解释视网膜神经纤维层厚度 (NFLT),神经纤维层毛细血管密度 (NFLP-CD) 和状细胞复合体厚度 (GCCT).
研究的目的:
- 调查折射误差如何影响通过OCT和OCTA获得的部门诊断参数.
- 评估阿米特罗皮亚对特定眼睛结构的影响,这与眼的检测有关.
主要方法:
- 从香港FAMILY队列中对791名参与者 (1339只眼睛) 的横截面研究.
- 通过球形等效折射对眼睛的分层:高近视,低近视,血缩视和高近视.
- 使用多变量破棒回归模型对部门NFLT,NFLP-CD和GCCT进行分析,并根据年龄,性别和信号强度进行调整.
主要成果:
- 与美相关的共变量明显影响了大多数NFLT部门,下半球GCCT,以及一半的NFLP-CD部门,而不是全球参数.
- 由于折射误差,在特定领域观察到高的假阳性率.
- 具体行业的轴长度 (AL) 和球体等效 (SE) 调整有效地降低了这些高的假阳性率.
结论:
- 由于折射误差导致的光学放大对OCT/OCTA部门参数的影响比全球参数更为明显.
- 个性化,特定于行业的AL和SE调整对于减轻放大偏差至关重要.
- 在商业OCT系统中实施这些基于部门的调整可以通过减少与折射误差相关的假阳性来提高青光眼的诊断准确性.
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