系统性免疫炎症指数和牙周炎之间的J形关联:来自NHANES 2009-2014年的结果
Ruoyan Cao1, Chen Li1, Fengxue Geng1
1Department of Periodontics, Liaoning Provincial Key Laboratory of Oral Diseases, School and Hospital of Stomatology, China Medical University, Shenyang, China.
Journal of periodontology
|September 15, 2023
概括
系统性免疫炎症指数 (SII) 显示了美国成年人的牙周炎与J形联系. 这一发现可能有助于开发基于免疫反应的牙周炎新疗法.
科学领域:
- 免疫学 免疫学 免疫学
- 牙周病学 牙周病学
- 公共卫生 公共卫生
背景情况:
- 牙周炎是一种常见的口腔炎症状况.
- 系统性免疫炎症指数 (SII) 反映了系统性炎症.
- 了解SII和牙周炎之间的关系对于公共卫生至关重要.
研究的目的:
- 调查系统性免疫炎症指数 (SII) 和牙周炎之间的关联.
- 在这种关系中识别潜在的效果修饰因素.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 数据进行的横截面研究 (2009-2014,N=10,301).
- SII计算为 (中性粒细胞×血小板) /淋巴细胞.
- 牙周炎是根据CDC/AAP标准定义的.
- 使用了自然立方线和多变量逻辑回归分析.
主要成果:
- 在SII和牙周炎之间观察到J形关联 (p < 0.001).
- 牙周炎风险降低了较低的SII水平 (log2(SII) ≤8.66),特别是在非西班牙裔白人中.
- 牙周炎风险随着SII水平较高 (log2(SII>8.66) 的增加.
- 对于探测口袋深度和临床附着损失也发现了类似的趋势.
结论:
- 在美国成年人中,SII和牙周炎之间存在一个J形关联,其拐点为log2(SII) = 8.66.
- 这种关系可能会为牙周炎的辅助治疗策略提供信息,考虑到免疫反应状态.
- 需要进一步的前性研究来验证这些发现.
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