麻醉后护理单位的恢复时间根据临床实践中使用的挥发性麻醉剂
Juraj Sprung1, Atousa Deljou1, David O Warner2
1From the Department of Anesthesiology and Perioperative Medicine.
Anesthesia and analgesia
|September 15, 2023
概括
挥发性麻醉剂溶解度对麻醉后护理单位 (PACU) 恢复时间的影响最小. 虽然过度静止发生在异氨酸中较多,但药物之间的恢复时间差异在临床上并不显著.
科学领域:
- 麻醉学和外科手术期间的医学.
- 药理学和药物新陈代谢
- 临床结果研究研究
背景情况:
- 挥发性麻醉剂溶解度对麻醉后恢复时间的影响在临床实践中仍然不清楚.
- 研究了三种挥发性药物 (异花,脱花,花) 与麻醉后护理单位 (PACU) 恢复时间和过度静止之间的关联.
- 假设更高的麻醉溶解度与长时间的PACU恢复和增加过度静止相关.
研究的目的:
- 确定挥发性麻醉剂溶解度对麻醉后护理单位 (PACU) 康复时间的临床影响.
- 评估不同挥发性麻醉剂与过度镇静发生率之间的关系.
- 为了确定影响PACU放电延迟的因素.
主要方法:
- 对47847名成年患者进行了回顾性观察性研究,这些患者接受了使用挥发性剂的全身麻醉.
- 主要结局:PACU恢复时间;次要结局:过度镇静 (Richmond兴奋镇静量表得分≤-3).
- 用于混调整的治疗权重反向概率 (IPTW);与邦费罗尼校正 (P < .017) 进行对对比.
主要成果:
- 与异黄相比,sevoflurane显示出一个统计学上显著的,但很小的 (4%),较短的PACU恢复时间.
- 在desflurane和其他药物之间没有发现PACU恢复时间的显著差异.
- 与sevoflurane和isoflurane相比,desflurane的过度化率明显较低;然而,这些差异没有显著影响PACU总体恢复时间.
结论:
- 在PACU恢复时间中,isoflurane,desflurane和sevoflurane之间的临床差异很小,并且在临床上没有显著意义.
- 虽然过度沉率有所不同,但它们并没有转化为PACU整体恢复时间的有意义差异.
- 减少PACU恢复时间的策略应专注于除了选择挥发性麻醉剂之外的因素.
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