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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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面向瘤异常的纳米医学设计

Quan Zhou1,2,3, Jiajia Xiang1,2,3, Nasha Qiu1,2

  • 1Zhejiang Key Laboratory of Smart Biomaterials and Center for Bionanoengineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China.

Chemical reviews
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PubMed
概括

刺激响应纳米药物利用瘤微环境 (TME) 异常来提高癌症治疗效率并减少副作用. 这篇评论详细介绍了他们的设计原则和临床翻译挑战.

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科学领域:

  • 在瘤学瘤学.
  • 纳米医学是一种纳米医学.
  • 生物医学工程 生物医学工程

背景情况:

  • 与传统化疗相比,抗癌纳米药物提供了更好的副作用概况.
  • 提高纳米药物的疗效仍然是癌症治疗中的重大挑战.
  • 正在开发响应刺激的纳米药物,通过向瘤微环境 (TME) 异常来克服生物限制.

研究的目的:

  • 量化TME内的病理异常,可以作为纳米医药设计的内源性刺激.
  • 提供关于用于癌症治疗的刺激响应纳米药物的当前知识的全面概述.
  • 讨论设计纳米药物的策略,以解决药物输送障碍.

主要方法:

  • 对TME病理异常和刺激响应纳米药物现有文献的审查和分析.
  • 剖析癌症药物递送过程和相关障碍.
  • 讨论刺激响应纳米药物的设计原则和整合策略 ("all-in-one"",one-for-all").

主要成果:

  • 确定TME病理异常作为针对性纳米药物激活的潜在触发因素.
  • 阐明使用刺激响应系统克服药物输送挑战的关键设计考虑因素.
  • 探索开发先进纳米药物的综合战略.

结论:

  • 刺激响应纳米药物在增强癌症治疗效率和减少副作用方面具有显著的前景.
  • 了解和利用TME异常对于设计有效的纳米医学平台至关重要.
  • 需要进一步的研究和开发,以应对这些先进的纳米药物的临床转化方面的挑战.