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Updated: Jul 16, 2025

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在急性淋巴细胞白血病中,DUX4-r 具有依赖 GTF2I 的新型活性

Daniele Campolungo1, Mara Salomé1, Beatrice Biferali1

  • 1Gene Expression and Muscular Dystrophy Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, 20132 Milano, Italy.

Science advances
|September 15, 2023
PubMed
概括

重组的双同源盒4 (DUX4-r) 通过改变的蛋白质相互作用驱动B细胞急性淋巴细胞白血病 (B-ALL). 准通用转录因子2I (GTF2I) 显示出治疗这种DUX4-r驱动型白血病的前景.

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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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