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Updated: Jul 16, 2025

Machine Learning Algorithms for Early Detection of Bone Metastases in an Experimental Rat Model
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Published on: August 16, 2020

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一个机器学习框架,以改善老鼠清除预测,并告知基于生理学的药理动力学建模

Andrea Andrews-Morger1, Michael Reutlinger1, Neil Parrott1

  • 1Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

Molecular pharmaceutics
|September 15, 2023
PubMed
概括

机器学习模型准确地预测了生理学基础的药理动力学 (PBPK) 模型的未结合的内在清除 (CLint,u). 与传统方法相比,这种方法可以改善体内清除率的预测,减少对大量体外数据的需求.

关键词:
在IVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIVIV在 PBPK 建模中使用 PBPK 模型.通过许可证的许可证.机器学习是机器学习.经过充分动的模型模型.

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