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一种用于粘膜疫苗接种的合成输送载体

Anne Billet¹, Justine Hadjerci², Thi Tran³

¹Institut Curie, Université PSL, Cellular and Chemical Biology Unit, U1143 INSERM, UMR3666 CNRS, 26 Rue d'Ulm, 75248, Paris, Cedex 05, France; Université de Paris, 85 boulevard Saint-Germain, 75006, Paris, France.

|September 15, 2023

概括

研究人员开发了一种用于粘膜疫苗的合成STxB蛋白. 这种新的输送工具有效地诱导针对SARS-CoV-2和HPV的免疫反应,解决当前mRNA疫苗的局限性.

科学领域:

疫苗学疫苗学疫苗学
免疫学免疫学免疫学
蛋白质化学蛋白质化学

背景情况:

mRNA疫苗对COVID-19取得了成功,但存在一些局限性.
目前的疫苗显示出适度的CD8+T细胞反应,缺乏粘膜免疫力.
粘膜免疫对于防止病毒在一般人群中传播至关重要.

研究的目的:

开发一种新型的树突细胞向粘膜疫苗接种载体.
为提高疫苗有效性创建一种合成输送工具.
为了生成用于抗原合和粘膜免疫的STxB变体.

主要方法:

有效的化学合成和在体外折叠的同型米素STxB蛋白质.
产生STxB变体,具有用于抗原结合的生物坐标手柄.
在小鼠模型中注射STxB抗原合物的鼻腔内注射.

主要成果:

合成STxB表现出与重组STxB相似的生物物理和细胞内贩运.
化学合的STxB变体成功输送了SARS-CoV-2和HPV抗原.
鼻腔内接种引发了强大的粘膜免疫,包括常存记忆CD8+T细胞和IgA抗体.

结论:

一种新的合成抗原输送工具STxB被开发用于粘膜疫苗接种.
这种方法克服了mRNA疫苗的局限性,通过诱导强大的粘膜免疫.
合成的STxB载体具有很大的潜力,可以解决传染病预防方面的紧急医疗需求.

关键词:

粘膜免疫力粘膜免疫力定居记忆T细胞定居记忆T细胞石家庄毒素B亚单元石家庄毒素B亚单元固相合成固相合成疫苗接种疫苗接种

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